Molecular basis for substrate recruitment to the PRMT5 methylosome
K. M. Mulvaney, C. Blomquist, N. Acharya, R. Li, M. OKeefe, M. Ranaghan, M. Stokes, A. J. Nelson, S. S. Jain, J. Columbus, F. K. Bozal, A. Skepner, D. Raymond, D. C. McKinney, Y. Freyzon, , W. R. Sellers
The paper identifies a conserved peptide sequence in PRMT5 substrate adaptors that mediates their interaction with PRMT5 and shows its necessity for methylation of substrates like spliceosome, histones, and ribosome complexes.
bioRxiv · Aug 22, 2020Cancer Biology