The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) recruits CoREST transcription repressor complexes to silence HIV following proviral reactivation in microglial cells
F. Ye, D. Alvarez-Carbonell, K. Nguyen, S. Valadkhan, K. Leskov, Y. Garcia-Mesa, S. Sreeram, J. Karn
This study shows that Nurr1 agonists enhance HIV silencing in microglial cells by recruiting CoREST repressor complexes to the HIV promoter, promoting latency and reducing neuroinflammation.
bioRxiv · Nov 16, 2021 · PreprintMicrobiology