K. Leskov

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) recruits CoREST transcription repressor complexes to silence HIV following proviral reactivation in microglial cells

This study shows that Nurr1 agonists enhance HIV silencing in microglial cells by recruiting CoREST repressor complexes to the HIV promoter, promoting latency and reducing neuroinflammation.

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

The paper shows that glycolysis downregulation is a hallmark of HIV-1 latency and that targeting antioxidant pathways can reactivate latent HIV-1.