The scar constituent Collagen I triggers coordinated collective migration and invasion in a 3D spheroid model of early endometriotic lesions
A. Stejskalova, V. Fincke, M. Nowak, Y. Schmidt, M.-K. von Wahlde, S. D. Schäfer, L. Kiesel, B. Greve, M. Götte
This paper develops a 3D spheroid model to study endometriotic lesion invasion, finding that collagen I promotes lesion formation and that Rac-signalling and miR-145 enhance collective migration.
bioRxiv · Apr 2, 2020 · PreprintBioengineering