In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.
V. D. Meshram, R. Balaji, P. Saravanan, Y. Subbamanda, W. Deeksha, A. Bajpai, H. Joshi, A. Bhargava, B. K. Patel
This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.
bioRxiv · Dec 22, 2023 · PreprintBiochemistry