H. Joshi

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection

This study shows that heterologous immunization primes antigen-specific memory CD4 T cells, enhancing early germinal center response but not antibody generation in influenza infection.

Estimation of Interaction and Growth Parameters to Develop a Computational Model for Gut Bacteria

This paper develops a computational model to estimate interaction and growth parameters of gut bacteria using cross-sectional data without longitudinal followup.

Interpretation of Predictions in Drug-Gut Bacteria Interactions Using Machine Learning

This study uses interpretable machine learning to identify key physicochemical features of drugs that influence their interactions with gut bacteria, finding that positively charged drugs inhibit bacterial growth while negatively charged drugs are more likely to be metabolized.

DNA Origami Voltage Sensors for Transmembrane Potentials with Single-Molecule Sensitivity

The paper develops DNA origami-based voltage sensors with single-molecule sensitivity, showing a 5% FRET change for 100 mV transmembrane potential shifts.