Mechanistic origin of different binding affinities of SARS-CoV and SARS-CoV-2 spike RBDs to human ACE2
Z.-B. Zhang, Y.-L. Xia, J.-X. Shen, W.-W. Du, Y.-X. Fu, S.-Q. Liu
This study identifies the molecular mechanisms behind the higher ACE2 binding affinity of SARS-CoV-2 RBD compared to SARS-CoV RBD using computational methods.
bioRxiv · Feb 5, 2022Biophysics