Cell BiologybioRxiv
Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen sensing pathways in mammalian cells
Y.-M. Tian, P. Holdship, T. Q. To…·T. P. Keeley
This study compares the oxygen-sensing mechanisms of ADO and PHD enzymes, finding they regulate substrate stability with similar O2-sensitivity but differ in metal sensitivity and hypoxic feedback.
DOI 10.1016/j.jbc.2023.105156