Oxidative Stress-Induced Microglial CD22 Upregulation Impairs Phagocytosis and Exacerbates Huntingtons Disease
Yan Hua Lee, Jian Jing Siew, Chia‐Wei Lee, Hui‐Mei Chen, Ya-Ting Lu, Deepa Sridharan, Po‐Chun Huang, Hua-Chien Chang, Shih-Yun Guu, Pao-Yuan Wang, Yi-Fu Wang, Suh-Yuen Liang, Feng‐Lan Chiu, Hung‐Chih Kuo, Kay‐Hooi Khoo, , Yijuang Chern
This study identifies CD22 upregulation in microglia due to oxidative stress in HD, which impairs phagocytosis and worsens disease progression.
Molecular Neurodegeneration · Oct 1, 2026Peer-reviewedNeuroscience