Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex
Diane D. Shao, Yifan Zhao, Joseph Brew, Yahia Adla, Urmi Ghosh, Vinay Viswanadham, Lovelace J. Luquette, Sijing Zhao, Andrea J. Kriz, Xuyu Qian, Takumi Taketomi, Shannon Coy, Sandro Santagata, Michael B. Miller, Fuminori Tsuruta, , Christopher A. Walsh
The paper investigates somatic copy number variants (CNVs) in human neurons across development, finding that perinatal elimination of neurons with aberrant genomes reduces CNV prevalence and targets dosage-sensitive genes.
Nature · Oct 28, 2026Peer-reviewedNeuroscience