Author

Yan Leng

National Institute of Mental Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 3

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Mario Alexander PenzoiD· 3 shared Claire GaoiD· 2 shared ABDEL G. ELKAHLOUNiD· 1 shared Anton SchulmanniD· 1 shared Arghya MukherjeeiD· 1 shared Ariel J. LevineiD· 1 shared Armin RaznahaniD· 1 shared Bruno B. AverbeckiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

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10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Mario Alexander PenzoORCID

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3 papers

Recent·Most cited

A synaptic mechanism for encoding the learned value of action-derived safety

Emma E. Macdonald, Jun Ma, Di Liu, Kai Yu, Rachel A. Walker, Michael E. Authement, Yan Leng, Hannah C Goldbach, Guochuan Li, Yulong Li, Veronica A. Alvarez, Bruno B. Averbeck, Mario Alexander Penzo

The paper identifies a thalamostriatal circuit mechanism by which internally constructed outcomes, like safety, acquire motivational value through synaptic plasticity in mice.

Nature Communications · Jun 4, 2026Peer-reviewedNeuroscience

A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus

Anton Schulmann, Ningping Feng, Pavan Kumar Auluck, Arghya Mukherjee, Ruchi Komal, Yan Leng, Claire Gao, Sarah K. Williams, Snehashis Roy, Ted Björn Usdin, Qing Xu, Vesna Imamovic, Yash Patel, Nirmala Akula, Armin Raznahan, , Francis J. McMahon

The paper identifies a conserved excitatory neuron gradient in human mediodorsal thalamus using single-nucleus and spatial transcriptomics, linking it to psychiatric disorder risk.

bioRxiv · Sep 3, 2024 · PreprintNeuroscience

Molecular and spatial profiling of the paraventricular nucleus of the thalamus

Claire Gao, Chiraag Gohel, Yan Leng, Jun Ma, David A Goldman, Ariel J. Levine, Mario Alexander Penzo

The paper identifies five molecularly distinct PVT neuronal subtypes using snRNA-seq and reveals their spatial organization and connectivity with cortical areas.

eLife · Mar 3, 2023Peer-reviewedNeuroscience