Mechanical confinement drives monocyte-to-macrophage differentiation
Wei Liu, Xuezhu Chen, Hao Zhang, Xue Bai, Yong Du, Yu-Xin Ji, Run-Yuan Mao, Ya-Jun Wang, Mengyao Sheng, Hai Gao, Fei Chen, Guangyin Jing, Xinxin Huang, Zhengjun Chen, Yan-Jun Liu
This study shows mechanical confinement drives monocyte-to-macrophage differentiation via a mechanoepigenetic pathway involving KDM6B and H3K27me3 demethylation.
bioRxiv · Apr 1, 2026 · PreprintCell Biology