Inhibition of the melanocortin-3 receptor (MC3R) causes generalized sensitization to anorectic agents
Naima S. Dahir, Yijun Gui, Yanan Wu, Patrick R. Sweeney, Savannah Y. Williams, Luis E. Gimenez, Tomi K. Sawyer, Stephen T. Joy, Anna K. Mapp, Roger D. Cone
This study shows that inhibiting MC3R increases sensitivity to anorectic agents like GLP1, PYY, CCK, and leptin, suggesting MC3R as a negative regulator of feeding behavior.
bioRxiv · Dec 5, 2023 · PreprintNeuroscience