Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization
Xuanyu Nan, Yujie Li, Rui Zhang, Ruoke Wang, Niannian Lv, Jiayi Li, Yuanfang Chen, Bini Zhou, Yangjunqi Wang, Ziyi Wang, Jiayi Zhu, Jing Chen, Jinqian Li, Wenlong Chen, Qi Zhang, , Yuhe Renee Yang
This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.
Nature Communications · Dec 4, 2024Peer-reviewedImmunology