Temporary deterioration of health and behavior during pexidartinib-mediated microglia depletion and repopulation in progranulin-deficient mice
Marc-Philipp Weyer, Lisa Hahnefeld, Luisa Franck, Yannick Schreiber, Carlo Angioni, Michael K. E. Schaefer, Irmgard Tegeder
This study shows that microglia depletion in progranulin-deficient mice causes temporary health and behavioral deterioration, with lasting proinflammatory effects in the brain.
bioRxiv · Apr 21, 2026 · PreprintNeuroscience