In situ loading of biologics on and tissue redirection of circulating extracellular vesicles with an anchoring nanobody
Gang Han, Li Zhong, Huanan Yu, Rongyan He, Yi Lu, Biaobiao Wang, Boyue Wu, Tongyang Zou, Xi Chen, Jingqiao Wu, Yao Zhang, Toshifumi Yokota, Yiqi Seow, 尹海芳
This paper demonstrates that NEV3, an EV-anchoring nanobody, enables in situ loading of proteins onto circulating extracellular vesicles and redirects them to specific tissues in vivo.
bioRxiv · Oct 28, 2026 · PreprintBioengineering