Xi Chen

2'-O-Methylated ncRNA condensates form a recombination center for IgH synapsis

This study shows that FBL-mediated 2'-O-methylation of GLTs forms condensates that drive IgH synapsis and CSR in B cells.

In situ loading of biologics on and tissue redirection of circulating extracellular vesicles with an anchoring nanobody

This paper demonstrates that NEV3, an EV-anchoring nanobody, enables in situ loading of proteins onto circulating extracellular vesicles and redirects them to specific tissues in vivo.

STRIP2 promotes colorectal cancer malignant progression via stabilizing LCN2 to suppress ferroptosis

This study identifies STRIP2 as a driver of colorectal cancer progression by stabilizing LCN2 to suppress ferroptosis, offering potential diagnostic and therapeutic implications.

Comprehensive cellular analysis with single-nucleus RNA-seq of archived PAXgene whole blood samples

The paper develops a method for single-nucleus RNA-seq of archived PAXgene whole blood samples, achieving high nuclei yields and unbiased cell-type representation through optimized isolation and globin depletion.

Phosphatidylserine exposure by developing astrocytes initiates microglia-mediated developmental cell death

The paper shows that phosphatidylserine exposure by developing astrocytes triggers microglia-mediated cell death, leading to vascular defects in the retina and cerebral cortex.

Macrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade

The paper identifies tetrads as a multicellular immune unit that correlates with antitumor immunity and response to checkpoint blockade in mouse and human tumors.

SPARP-seq reveals poly(A) tail shortening as a hallmark of the active human translatome

The paper introduces SPARP-seq, a method combining poly(A) assessment and ribosome profiling to show poly(A) tail shortening is a hallmark of active translation in human cells.

The Aging Epigenome: Integrative Analyses Reveal Functional Overlap with Alzheimer's Disease

This study identifies age-associated DNA methylation changes in blood and their overlap with Alzheimer's disease by analyzing two cohorts and finding shared genetic variants and CpGs associated with both aging and AD.

PIB: Parallel ion beam etching of sections collected on wafer for ultra large-scale connectomics

The paper introduces a parallel ion beam etching method for thinning sections on a wafer, enabling high-resolution volumetric imaging for connectomics.

CRISPR screens reveal ZBTB17/MIZ1 as a peroxisome regulator

This study identifies ZBTB17/MIZ1 as a peroxisome regulator through CRISPR screens, showing its role in protein import and metabolic regulation.

Real-time Zika risk assessment in the United States

This paper develops a real-time risk assessment framework for Zika Virus in the US, identifying regions at risk of importation and sustained transmission.