Yi Wu

A two-step organoid screen identifies transient p53 activation as a senolytic strategy for radiation-induced salivary gland dysfunction

The paper identifies Nutlin3a as a senolytic compound that reduces radiation-induced salivary gland dysfunction by transiently activating p53 in a two-step organoid screening approach.

RegimeFormer: A Large Protein Model of Global Perturbation Regimes

RegimeFormer identifies protein perturbation regimes using a large-scale model and atlas, improving prediction accuracy and enabling downstream applications.

Regulation of Chlamydia trachomatis infection in the female genital tract by type I and type II interferons

This study shows type I and II interferons have distinct and overlapping roles in controlling Chlamydia trachomatis infection in the female genital tract, with type I acting earlier and type II later, and both critical for suppression at different stages and locations.

Identification of collaborative cross mouse strains susceptible to chlamydial induction of hydrosalpinx

This study identifies Collaborative Cross mouse strains susceptible to chlamydial induction of hydrosalpinx, revealing strain-specific differences in infection and pathology outcomes.

Notch Signaling Drives Pro-Regenerative and Migratory Traits in Glandular Stem/Progenitor Cells

The paper identifies Notch signaling as essential for maintaining stem/progenitor cell self-renewal and migration post-irradiation in salivary and other gland organoids.

Spatiotemporal dynamics of Hemerocallis citrina habitat suitability in China under climate change scenarios

This study predicts the future spatiotemporal distribution of Hemerocallis citrina under climate change scenarios using environmental modeling and GIS tools.

Robust Estimation of Bacterial Cell Count from Optical Density

The paper evaluates three OD calibration protocols for bacterial cell count estimation and recommends serial dilution of silica microspheres for its precision and compatibility with flow cytometry.

In vivo Imaging β-cell Function Reveals Two Waves of β-cell Maturation

This study uses in vivo imaging in zebrafish to show that β-cell maturation occurs in two waves, initiated by low glucose and boosted by increased glucose delivery, with calcineurin/NFAT activation playing a key role.