Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer
Jiayan Wu, Yingyao Lai, Jinming Li, Lixiang Zhai, Pallavi Asthana, Lexin Chen, Minting Chen, Baisen Chen, Susma Gurung, Jin Lyu, Yijing Zhang, Lin Tao Lü, Shuojie Huang, Weihong Kuang, Hui Shi, , Hoi Leong Xavier Wong
This paper identifies 4-C-3 as an antitumor metabolite derived from cholesterol by gut microbiota, showing its efficacy in CRC models through dual inhibition of EGFR and KRAS.
bioRxiv · May 2, 2025 · PreprintCancer Biology