Cancer BiologybioRxivPreprint
Metabolic modulation of intratumoral cholesterol with gut microbiota for the treatment of colorectal cancer
Jiayan Wu, Yingyao Lai, Jinming Li…·Hoi Leong Xavier Wong
This paper identifies 4-C-3 as an antitumor metabolite derived from cholesterol by gut microbiota, showing its efficacy in CRC models through dual inhibition of EGFR and KRAS.
DOI 10.1101/2025.05.02.651972