FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage
Jianfeng Lv, Jianhan Sun, Yunbin Luo, Juntao Liu, Di Wu, Yiyu Fang, Haoyang Lan, Longfei Diao, Yuqi Ma, Yuan Li, Meizhi Wang, Ziming Zhao, Heming Wang, Austin Morris, Wenkang Zhang, , Xueqing Yan
This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.
MedComm · Oct 30, 2025Peer-reviewedBiophysics