Longitudinal analysis of retinal cell state transitions in RB1-deficient retinal organoids reveals the nascent cone precursors are the earliest cell-origin of human retinoblastoma
Ke Ye, Yuan Wang, Ping Xu, Bingbing Xie, Shijing Wu, Wenxin Zhang, Guanjie Gao, Dandan Zheng, Xiaojing Song, Suai Zhang, Fuying Guo, Yongping Li, Yizhi Liu, Jie Wang, Ruifang Sui, Xiufeng Zhong
This study identifies ATOH7+ nascent cone precursors as the earliest cell-of-origin for human retinoblastoma using RB1-deficient retinal organoids and scRNA-seq.
Cell Death and Disease · Jan 14, 2026Peer-reviewedCell Biology