EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer
Hanbyeol Kim, Do‐Gyun Kim, Seongyun Ha, Jun-Young Jang, Francisca N. de Luna Vitorino, Joanna M. Gongora, Woochul Kim, Yoonji Oh, Gyeongsik Park, Hyeji Kang, Soo-Hyun Im, Chan Kwon Jung, Seon-Young Kim, Inkyung Jung, Jae‐Kyung Won, , Chul‐Hwan Lee
This study shows that the EZH1Q571R mutation enhances chromatin compaction and PRC2 activity, leading to repression of tumor suppressor genes in follicular thyroid cancer.
bioRxiv · May 6, 2025 · PreprintMolecular Biology