Organoid modeling of tumor-associated macrophages reveals phagocytosis checkpoint blockade-induced conversion to an immunosuppressive SPP1+ phenotype
Michitaka Nakano, Lyong Heo, Yu-Ping Yang, Lorena P. Munoz, Yihua Liu, Lei Zhao, Juhyung Park, Eirini Tsekitsidou, Anthony Francois, Jie Liu, Aaron C. Trotman-Grant, Maria Fernanda Henao Echeverri, Cara Coleen Rada, Edward Tran, Arya Khokhar, , Calvin Jay Kuo
The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.
bioRxiv · May 9, 2026 · PreprintCancer Biology