Calvin Jay Kuo

This study establishes patient-derived melanoma organoids (PDMOs) that retain tumor-immune heterogeneity and show context-dependent responses to immune checkpoint blockade.

The paper uses patient-derived organoids to study TAM responses to CD47 checkpoint blockade, revealing a conversion to an immunosuppressive SPP1+ phenotype in clear cell renal cell carcinoma.

This study uses a CRISPR-based method to investigate ecDNA formation, showing efficient circularization and distinct repair pathways for ecDNA and chromosomal scars.

The paper introduces the colocatome, a spatial-omic framework, to compare microenvironment features between tumour-stroma assembloids and lung cancer specimens, finding that fibroblasts protect cancer cells from treatment by reorganizing cytoarchitecture.

The paper identifies R-SPONDIN2-expressing mesenchymal cells as a niche for lung bud tip progenitors using single-cell RNA sequencing and functional experiments.

The paper describes engineered surrogate R-spondins that enhance Wnt signaling in specific cell types by bypassing natural receptor interactions.

This paper identifies HAT1 as a gene that links nutrient metabolism to histone production through a gene-metabolite circuit, showing its role in cell proliferation and its association with cancer outcomes.