Benchmarking zero-shot single-cell foundation model embeddings for cellular dynamics reconstruction
Xueya Zhou, Zihan Wang, Yue Ling, Qinxue Tian, Zhenyi Zhang, Yongge Li, Luonan Chen, Peijie Zhou
This study benchmarks zero-shot single-cell foundation model embeddings for cellular dynamics reconstruction and finds they underperform a traditional HVG baseline in capturing complex temporal patterns.
bioRxiv · Mar 12, 2026 · PreprintBioinformatics