AKR1C mediates the acquired resistance to T-Dxd in a HER-2 positive gastric cancer line
Dong Wang, Qinqin Huang, Peili Wang, Feng Tang, Yuhe Han, Xiangyi Wang, Jing Huang, Liqi Shi, Weiqun Cao, Zhixiang Zhang, Qingyang Gu
This study identifies AKR1C as a mediator of T-Dxd resistance in HER2-positive gastric cancer cells through gene expression and functional assays.
bioRxiv · Dec 11, 2024 · PreprintCancer Biology