Dong Wang

De novo design of functional RNAs through higher-order interactions

This paper introduces DS3dRNA, a framework for de novo RNA design that uses higher-order interactions, achieving better performance than existing methods in structure prediction and function recovery.

ERFMTDA: Predicting tsRNA-disease associations using an enhanced rotative factorization machine

ERFMTDA predicts tsRNA-disease associations by modeling complex feature interactions and using a biologically informed negative sampling strategy, outperforming existing methods.

Complex genetic architecture underlying the plasticity of tobacco leaf width provides insight into across-environment genomic prediction

This study identifies QTLs associated with leaf width and its plasticity in tobacco and develops a GEAI model for cross-environment prediction, improving accuracy by 8.7%.

AetherCell: A generative engine for virtual cell perturbation and in vivo drug discovery

AetherCell is a generative model that unifies clinical and experimental data to predict drug responses and repurpose existing drugs in human contexts.

Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion

This study uses adipose-mimetic hydrogels to show that soft mechanical cues from adipocytes enhance breast cancer cell invasion by altering ECM structure and cellular confinement.

AKR1C mediates the acquired resistance to T-Dxd in a HER-2 positive gastric cancer line

This study identifies AKR1C as a mediator of T-Dxd resistance in HER2-positive gastric cancer cells through gene expression and functional assays.

Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Metastasis

This study shows that epigenetic reprogramming of tissue-specific transcription in cancer cells promotes metastasis, with FOXA2 playing a key role in liver colonization by metastatic colorectal cancer cells.

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

The paper identifies recurrently deregulated lncRNAs in HCC and PVTT samples, linking them to metastasis and prognosis using multi-omics data.