Striatal M4 Receptors Mediate M4 PAM Antipsychotic-like Efficacy Independently of Normalizing Striatal Dopamine Release
Daniel G Joyner, Curran M. Johnston, Yumin Choi, Michael N. May, Rebecca D Carden, Daniel J. Foster
This study shows that M4 receptor PAMs have antipsychotic-like effects through dorsal striatal postsynaptic mechanisms, independent of changes in dopamine release.
bioRxiv · Oct 27, 2026 · PreprintPharmacology & Toxicology