Ctcf deficiency in myofibers induces pathological genome reprogramming toward the spontaneous development of myopathy
Jimmy Massenet, Chiara Nicoletti, Luca Caputo, Sören S. Hüttner, Monica M Nicolau, Jesus R Barajas, Maira Rossi, Yuqing Yang, Yu Xin Wang, Tom H. Cheung, Michael Witcher, Colin G. Crist, Prem Puri
This study shows that Ctcf deficiency in myofibers leads to genome reprogramming and myopathy by disrupting 3D genome structure and gene regulation.
bioRxiv · Oct 14, 2026 · PreprintMolecular Biology