Listeriolysin O recruits UBA1 to ubiquitinate NLRP3 and suppress inflammasome defence
Longwei Yuan, 丁安, Yuchao Feng, Xiaoqing Ming, Yuting Hu, Chen Yang, Mengchen Zhang, Yingkang Wang, Zheng Nie, Haibo Wu
This paper identifies a mechanism by which L. monocytogenes uses LLO to ubiquitinate NLRP3, suppressing inflammasome activation and enhancing bacterial survival.
bioRxiv · Sep 25, 2026 · PreprintMicrobiology