Author

Z. Meacham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Sharrar· 2 shared D. Rabuka· 2 shared J. Staples-Ager· 2 shared L. Arake de Tacca· 2 shared M. Schelle· 2 shared T. Collingwood· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

A. Sharrar

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2 papers

Recent·Most cited

BiochemistrybioRxivAug 28, 2023

Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

A. Sharrar, L. Arake de Tacca, Z. Meacham…·M. Schelle

This paper identifies and engineers a novel Cas12a nuclease (AiEvo2) with improved specificity and efficacy for human gene editing, including applications in Huntington's disease and CAR-T therapy.

DOI 10.1016/j.jbc.2024.105685

humanCRISPR screen

BiochemistrybioRxivPreprintFeb 3, 2023

μCas, a novel class of miniature type-V Cas12f nucleases with diverse PAM

A. Sharrar, L. Arake de Tacca, T. Collingwood…·M. Schelle

The paper describes μCas, a new class of small Cas12f nucleases with broader PAM preferences, enabling more genomic editing possibilities.

DOI 10.1101/2023.02.03.527072

humanexperimental assay