Nucleotide binding is the critical regulator of ABCG2 conformational transitions
Z. Gyöngy, G. Mocsar, E. Hegedus, T. Stockner, Z. Ritter, L. Homolya, A. Schamberger, T. I. Orban, J. Remenyik, G. Szakacs, K. Goda
This study investigates how nucleotide binding regulates conformational transitions in ABCG2, showing it induces the inward-to-outward facing switch and interacts with substrate binding.
bioRxiv · Oct 19, 2022Biochemistry