Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of wtf meiotic drivers
J.-X. Zheng, T.-Y. Du, G.-C. Shao, Z.-H. Ma, Z.-D. Jiang, W. Hu, F. Suo, W. He, M.-Q. Dong, L.-L. Du
The paper investigates how ubiquitination mediates the antagonistic duality of toxin and antidote proteins in fission yeast meiotic drivers, showing that ubiquitination promotes antidote localization to endosomes and neutralizes toxin activity.
bioRxiv · Jul 15, 2023 · PreprintCell Biology