W. Hu

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Hormonal dynamics reveal a stimulatory role for secretoneurin in zebrafish ovulation

This study shows that secretoneurin stimulates ovulation in zebrafish by increasing gene expression in the hypothalamic-pituitary-ovarian axis and inducing ovulation in anovulatory females.

The genomic and epigenomic dynamics of hemizygous genes across crops with contrasting mating systems

This study examines hemizygous genes in 22 crop genomes, finding higher hemizygosity in clonal lineages and distinct expression and epigenetic features compared to diploid genes.

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

A conserved lysine/arginine-rich motif in potyviral 6K1 protein is key in engaging autophagy-mediated self-degradation for completing pepper veinal mottle virus infection

This study identifies a conserved lysine/arginine-rich motif in potyviral 6K1 protein that mediates autophagy-mediated self-degradation, essential for viral infection.

GhCPK28 negatively regulates the immune response by phosphorylating GhTIFY3b

This study identifies GhCPK28 as a negative regulator of cotton immunity against Verticillium dahliae by phosphorylating and destabilizing GhTIFY3b, enhancing resistance when silenced.

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN

This study identifies a cancer persistent DNA repair circuit involving mtp53, MDM2, and MDMX that recruits 53BP1 and MDC1 to chromatin, enhancing cell survival.

"Two-Birds-One-Stone" Oral Nanotherapeutic Designed to Target Intestinal Integrins and Regulate Redox Homeostasis for Ulcerative Colitis Treatment

This paper develops an oral nanotherapeutic, OPNs@LMWH, that targets intestinal integrins and regulates redox homeostasis to treat ulcerative colitis, showing improved therapeutic efficacy and immune uptake.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

Heparan sulfate dependent phase separation of CCL5 and its chemotactic activity

This study shows that CCL5 and heparan sulfate form phase-separated gradients, which guide immune cell migration, and demonstrates this through in vitro and in vivo experiments.

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

The paper examines how human disturbance affects spatiotemporal associations among mountain forest terrestrial mammals using camera-trap data from the eastern Himalaya.

Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of wtf meiotic drivers

The paper investigates how ubiquitination mediates the antagonistic duality of toxin and antidote proteins in fission yeast meiotic drivers, showing that ubiquitination promotes antidote localization to endosomes and neutralizes toxin activity.

Proguanil and chlorhexidine augment the antibacterial activities of clarithromycin and rifampicin against Acinetobacter baumannii

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

CD99 Promotes Self-renewal in Hematopoietic Stem Cells and Leukemia Stem Cells by Regulating Protein Synthesis

This study shows CD99 regulates protein synthesis in hematopoietic stem cells and leukemia stem cells, promoting self-renewal and clonal expansion leading to AML.

TGFB1 Induces Fetal Reprogramming and Enhances Intestinal Regeneration

This study identifies TGFB1 as a key driver of fetal reprogramming and intestinal regeneration, showing its role in enhancing epithelial repair through a YAP-SOX9 transcriptional circuit.

Integrated transcriptome and lineage analyses reveal novel catecholaminergic cardiomyocytes contributing to the cardiac conduction system in murine heart

This study identifies a novel catecholaminergic cardiomyocyte population expressing Dbh that contributes to the murine cardiac conduction system through transcriptomic, genetic, and optogenetic analyses.

Genetic Dissection of Mutual Interference between Two Consecutively Learned Tasks in Drosophila

This study identifies distinct molecular mechanisms for proactive and retroactive interference in Drosophila during consecutive learning tasks.

The thermodynamic state of aerobic glycolytic flux plays a critical role in stabilizing aerobic glycolytic flux of cancer cells

This study identifies the thermodynamic state of aerobic glycolysis (TSAG) as a system property that stabilizes glycolytic flux in cancer cells, showing it resists perturbations and requires both enzyme inhibition and TSAG disruption for effective AG inhibition.

The N-terminal subunit of vitellogenin in planthopper eggs and saliva acts as a reliable elicitor that induces defenses in rice

This study shows that the N-terminal subunit of vitellogenin from planthoppers induces defense responses in rice, reducing egg hatching and attracting parasitoids.

Glutamine is essential for overcoming theimmunosuppressive microenvironment in malignant salivary gland tumors

This study shows that dietary glutamine supplementation enhances antitumor immunity by altering the tumor microenvironment in mice with malignant salivary gland tumors.

Piperlongumine (PL) conjugates induce targeted protein degradation

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

Topological supramolecular network enabled highly conductive and stretchable organic bioelectronics

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery

Suppression of B-Cell Activation by Human Cord Blood-Derived Stem Cells (CB-SC) through the Galectin-9-Dependent Cell Contact Mechanism

This study shows that human cord blood-derived stem cells suppress B-cell activation via a Gal-9-dependent cell contact mechanism and affect calcium levels and signaling pathways.

Targeting interactions between the Galectin-3 intrinsically disordered and structured domains based on long time-scale accelerated molecular dynamics

This study uses MD simulations and NMR to identify a binding cavity in Galectin-3's CTD that interacts with its disordered NTD, and designs an inhibitory peptide targeting this interface.

Drought restricted sucrose transport from outer cottonseed coat to fiber and further inhibited cellulose synthesis during cotton fiber thickening

This study shows drought reduces sucrose transport from cottonseed coat to fiber and disrupts sucrose allocation, leading to decreased cellulose synthesis and fiber strength.

ASER: Animal Sex Reversal database

ASER compiles sex reversal data from 18 species, including genes, regulatory networks, RNA-seq, and ISH images, to support research on animal breeding and human health.