Zane Hamdan

A large-scale single cell map of primary and conditional regulatory variation in the human brain

The paper maps primary and conditional regulatory variation in the human brain using single cell data, showing that conditional signals are more cell type-specific and better colocalize with disease GWAS loci.

Transiently-elevated dopamine triggers plasticity that preserves motor function, striatal neuron morphology, and thalamostriatal input in a mouse model of Parkinson's disease

The paper shows that temporarily increasing dopamine in a Parkinson's mouse model preserves motor function, neuron structure, and specific neural inputs.