Antibiotic Persistence Emerges from Cell-State-Driven Transcriptional Reprogramming
Qiang Liu, Zehui Yu, Xiaoli Liu, Amy Iverson, Tyler Simmons, Jason W. Rosch, Peijun Ma
The paper shows how transcriptional heterogeneity and redundancy in stress responses shape antibiotic persistence in Klebsiella pneumoniae using single-cell RNA sequencing and functional assays.
bioRxiv · Feb 17, 2026 · PreprintMicrobiology