Jason W. Rosch

This study shows that mucin promotes pneumococcal colonization by suppressing autolysis and modulating immune responses through tryptophan biosynthesis.

This study examines capsule switching in Streptococcus pneumoniae using whole-genome sequences, finding that switching is limited to specific capsule-type pairs and influenced by genetic and ecological factors.

This study shows that RNA quality control through rny mutations enables antibiotic tolerance in Streptococcus pneumoniae by balancing transcriptional resilience and degradation.

The paper shows how transcriptional heterogeneity and redundancy in stress responses shape antibiotic persistence in Klebsiella pneumoniae using single-cell RNA sequencing and functional assays.

This study identifies h18:0 as a toxic fatty acid produced by S. aureus that targets S. pneumoniae, and reveals genetic mechanisms allowing pneumococcus to resist its toxicity.

This paper shows pneumococcal extracellular vesicles carry DNA that can be transferred to competent cells via the transformation machinery, promoting horizontal gene transfer and potential antibiotic resistance spread.

This study shows that allergic inflammation in mice reduces severity of viral-bacterial co-infection by altering the lung microbiome and immune response.