Chronic stress abnormalize microglial-vascular interaction via AT1R signaling and microglia activation to drive depression-like behaviors
Hang Gao, Zeyuan Ding, Biao Xu, Yuqing Wu, Meizhen Zhu, Xiaoyue Zhang, Fujian Qi, Junru Liu, Quan Fang, Yanli Ran
This study shows that chronic stress disrupts microglial-vascular interactions via AT1R signaling and microglia activation, leading to vascular dysfunction and depression-like behaviors in mice.
bioRxiv · Dec 26, 2025 · PreprintNeuroscience