Dual blockade of IL-18 and IL-4Rα by a bispecific antibody for improved treatment of atopic dermatitis
Lijuan Zhang, Zhan Meng, Hui Bo, Ye Tian, 牟伟才, Xianqiang Ping, Junya Dong, You Leo Li
This paper evaluates a bispecific antibody targeting IL-18 and IL-4Rα for treating atopic dermatitis, showing improved suppression of multiple inflammatory pathways compared to single-target therapies.
bioRxiv · Oct 17, 2026 · PreprintImmunology