Zhao Chen

Autophagosome-tethering compounds selectively lower mutant ataxin-3 in preclinical models of spinocerebellar ataxia type 3

Small-molecule autophagosome-tethering compounds selectively lower mutant ataxin-3 through an LC3- and autophagy-dependent mechanism and improve disease-related phenotypes in preclinical models of SCA3.

Structural basis of DNA N6-adenine methylation in eukaryotes

This study determines the structural basis of DNA N6-adenine methylation by modeling the AMT1 complex and validating its function through mutagenesis.

A high-continuity and annotated reference genome of allotetraploid Siberian wildrye (Elymus sibiricus L., Poaceae: Triticeae)

This study presents a high-quality reference genome for the allotetraploid Siberian wildrye, revealing retrotransposon bursts, chromosomal translocations, and population structure, supporting the QTP as its origin.

Predicting biomarker for the acute pulmonary embolism by using gene ontology and machine learning

The paper uses gene ontology and machine learning to identify a gene expression signature for acute pulmonary embolism, achieving an AUC of 0.89 in distinguishing patients from controls.

Plasma cell-free DNA promise disease monitoring and tissue injury assessment of COVID-19

This study analyzes cell-free DNA in COVID-19 patients to show its potential for disease monitoring and tissue injury assessment.