Affinity Maturation Enables Dual Targeting of Cancer-Associated MUC1-Tn/STn and Drives Potent Tumor Control
Jinfeng Ye, Xueyong Zhu, Huinan Lu, Jessica D. Coppola, Ding Zhang, Yinping Tian, Zhuo Yang, Shereen Chung, Leigh-Anne Cui, Jinghao Zhi, Liuqing Wen, Jianzhong Xi, Ian A. Wilson, Joseph Jardine, Peng Wu
This study affinity-matures an antibody to recognize both MUC1-Tn and MUC1-STn glycoforms, enhancing its efficacy against heterogeneous tumors.
bioRxiv · Oct 26, 2026 · PreprintCancer Biology