Cancer BiologybioRxivPreprint
Cancer cell-selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumor immunotherapy
Ziyan Kong, Yile Wang, Yunqi Zhao…·Jinke Wang
This paper demonstrates a strategy to repurpose rituximab for solid tumors by selectively expressing CD20 on cancer cells, enhancing NK cell-mediated cytotoxicity and showing high specificity and safety in multiple models.
DOI 10.1101/2025.10.16.682764