Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease
Dingyi Luo, Lvqin Zheng, Ming Lu, Ziyao Chen, P Wang, Qiang Guo, Ning Gao
This study determines the Cryo-EM structure of the PHB complex and shows it organizes m-AAA proteases in mitochondrial microdomains to regulate proteolytic homeostasis.
Nature Communications · May 13, 2026Peer-reviewedMolecular Biology