Molecular anatomy of the glomerular filtration barrier reveals topology-encoded albumin sieving
Xing Wang, Weiyan Zheng, Wenjing Du, DONGXUAN CHI, Wenjia Fan, Ruoheng Mo, Jie Ding, Li Yang, Jing Nie, Ming Han, Qiang Guo
The paper uses cryo-ET and transport modeling to show that the glomerular basement membrane's void-network topology restricts albumin passage, explaining selectivity in the filtration barrier.
bioRxiv · Oct 18, 2026 · PreprintPhysiology