Stromal LOX/FAK/beta catenin pathway locks mammary fibroblasts into a tumor-promoting myCAF state
Armin Gandhi, Divya Beri, Dharma Pally…·Paturu Kondaiah
This study identifies LOX as a key mediator of TGF-β-induced myCAF state in breast cancer, showing its role in promoting tumor growth through a LOX/FAK/GSK3β/β-catenin pathway.