Daniel Heinzer

Human organoid screen links transient translational modulation to progenitor progression in corticogenesis

The paper screens human cortical organoids with small molecules to identify translational modulators affecting progenitor progression in corticogenesis, finding Emetine promotes neuronal differentiation.

Identification of protein aggregates in the aging vertebrate brain with prion-like andphase separation properties

The paper identifies prion-like and phase-separated protein aggregates in aging vertebrate brains using quantitative proteomics in killifish and validates their propagation and functional properties.

A screen of alkaline and oxidative formulations for their inactivation efficacy of metal surface adsorbed prions using a steel-bead seed amplification assay

This study screens alkaline and oxidative formulations for prion inactivation using a novel steel-bead seed amplification assay, identifying effective detergents for medical instrument decontamination.

An Arrayed Genome-Wide Perturbation Screen Identifies the Ribonucleoprotein hnRNP K As Rate-Limiting for Prion Propagation

The paper identifies Hnrnpk as a key regulator of prion propagation through a genome-wide RNAi screen using the QUIPPER assay, showing PSA's ability to reduce prion levels and toxicity in multiple models.

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

The paper identifies 38 genes regulating a-synuclein cell-to-cell transfer using an siRNA screen and shows genetic overlap with Parkinson's disease.

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

This study shows LAG3 is not expressed in human and mouse neurons and does not worsen α-synuclein pathology in vitro or in vivo.

Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference

This paper identifies 54 novel regulators of PrPC expression through a genome-wide RNA interference screen, with 9 confirmed by CRISPR interference, revealing potential therapeutic targets for prion diseases.

Prion infection, transmission and cytopathology modelled in a low-biohazard human cell line

The paper describes a human cell line, hovS, that can be infected with sheep-derived prions and exhibits prion-related cytopathology, offering a safer alternative to human prion studies.

Genome-wide transcriptomics identifies an early preclinical signature of prion infection

The paper identifies early molecular changes in prion-infected mice, suggesting glial pathophysiology as a key driver and potential targets for intervention.