Amador Gallardo

BMAL1 represses transposable elements independently of CLOCK in pluripotent cells

This study shows BMAL1 represses transposable elements in pluripotent cells independently of CLOCK, leading to genome-wide changes and totipotency features when BMAL1 is deleted.

Polycomb repression during S/G2 phases restrain initiation of cell differentiation to the G1 phase of the cell cycle

The paper shows that Polycomb repression during S/G2 phases restricts differentiation gene activation, allowing it to occur primarily in G1 phase in mouse ESCs.

Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells

The paper shows that PRC2 subunits are differentially recruited across the cell cycle in mESCs, enabling chromatin state changes that facilitate differentiation in G1.