Derek J. Van Booven

Divergent regulation of STING-mediated innate immune responses by CBP and p300

This study shows that CBP promotes STING-mediated transcription in the nucleus, while p300 suppresses STING signaling in the cytoplasm, with p300 inhibitors enhancing immune responses.

Targeting Endoplasmic Reticulum Stress and Nitroso-Redox Imbalance in Neuroendocrine Prostate Cancer: The Therapeutic Role of Nitric Oxide

This study identifies ER stress and nitroso-redox imbalance as key drivers of NEPC progression and shows that NO supplementation reduces tumor burden and metastasis in mice.

African origin haplotype protective for Alzheimer's disease in APOEϵ4 carriers: exploring potential mechanisms

The paper identifies an African-origin haplotype that reduces AD risk in APOEε4 carriers by 75% and explores its molecular mechanisms through sequencing and methylation analysis.

Gene expression and chromatin accessibility comparison in iPSC-derived microglia in African, European, and Amerindian genomes in Alzheimer's patients and controls.

An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression

This study identifies NUDT6 as an antisense transcript of FGF2, showing that its silencing enhances smooth muscle cell survival and limits vascular disease progression.

Generative Adversarial Networks Can Create High Quality Artificial Prostate Cancer Magnetic Resonance Images

This study uses GAN to generate high-quality synthetic prostate cancer MRI images, showing that even inexperienced users can misidentify them as real.

Converging evidence for differential regulatory control of APOEε4 on African versus European haplotypes

The paper identifies differential regulatory control of APOEε4 on African versus European haplotypes through enhancer activity and promoter interactions analyses.

Linkage Analysis in Caribbean Hispanic Families with Puerto Rican Ancestry Idenitfies an Alzheimer Disease Locus on chromosome 9.

The paper performs linkage analysis in Caribbean Hispanic families to identify an Alzheimer's disease locus on chromosome 9, finding a region with multiple candidate genes.

Optimized functional annotation of ChIP-seq data

geneXtendeR improves ChIP-seq peak annotation by considering multiple gene associations and adjusting for peak variability, enhancing functional interpretation.

SUPERmerge: ChIP-Seq Coverage Island Analysis Algorithm For Broad Histone Marks

SUPERmerge analyzes ChIP-seq read pileups to identify coverage islands in broad histone mark datasets at single base pair resolution.