David A. Davis

This study creates a single-nucleus transcriptomic atlas of Parkinson's disease progression, identifying cell-type-specific gene expression changes and linking them to genetic risk factors and disease stages.

The paper maps transcriptomic and chromatin accessibility profiles across 25 human brain regions and identifies genes linked to neuropsychiatric disorder risk.

The paper identifies an African-origin haplotype that reduces AD risk in APOEε4 carriers by 75% and explores its molecular mechanisms through sequencing and methylation analysis.

The paper investigates CAG repeat expansions and their association with cell death in specific brain regions in Huntington's disease using molecular profiling.

The paper identifies layer 5a corticostriatal neurons as selectively vulnerable in Huntington's disease using single nucleus RNA sequencing and shows they have extensive mHTT-CAG expansions.

This study generates a large single-cell RNA sequencing dataset of the human substantia nigra in Parkinson's disease, identifies DA neuron subtypes, and reveals molecular changes associated with PD.

The paper develops a multi-omic single-nucleus sequencing method and framework to analyze regulatory genome diversity in human cortical cells and link it to disease risk variants.

This paper introduces snmC-seq2, an improved single-cell DNA methylome profiling method that enhances read mapping, reduces artifacts, and increases throughput and coverage uniformity.